Synvisc and Orthovisc are viscosupplement injections. Made from a natural substance that lubricates and cushions your joint. Synvisc an injectable medication called hyaluronan. Injectable hyaluronan is often referred to by its most commonly known brand name of "Synvisc." Other brand names of hyaluronan include Orthovisc, Euflexxa, and Supartz. Synvisc is typically administered as a series of three injections into the knee joint, each injection spaced about one week apart. Synvisc has been shown to help alleviate arthritis symptoms for 6 months, and to delay the need for knee replacement surgery.